Table 2.
Summary statistics from linear regression analysis of the effect of schizophrenia-associated copy number variants (SZ-CNV) carrier status on the 15 subcortical brain volumes
| Subcortical volume | Nnon-carriers | Ncarriers | B | SE | p | pfdr |
|---|---|---|---|---|---|---|
| Thalamus (left) | 8511 | 47 | −0.18 | 0.09 | 0.052 | 0.097 |
| Thalamus (right) | 8515 | 47 | −0.21 | 0.09 | 0.016 | 0.048 |
| Caudate (left) | 8501 | 48 | −0.10 | 0.12 | 0.420 | 0.524 |
| Caudate (right) | 8514 | 48 | −0.08 | 0.12 | 0.511 | 0.582 |
| Putamen (left) | 8535 | 48 | −0.33 | 0.11 | 0.002 | 0.014 |
| Putamen (right) | 8525 | 47 | −0.23 | 0.11 | 0.028 | 0.070 |
| Pallidum (left) | 8472 | 46 | −0.26 | 0.12 | 0.036 | 0.076 |
| Pallidum (right) | 8480 | 47 | −0.36 | 0.12 | 0.003 | 0.014 |
| Hippocampus (left) | 8484 | 46 | −0.14 | 0.13 | 0.281 | 0.383 |
| Hippocampus (right) | 8460 | 47 | −0.48 | 0.13 | <0.001 | 0.002 |
| Amygdala (left) | 8540 | 46 | −0.03 | 0.14 | 0.827 | 0.827 |
| Amygdala (right) | 8526 | 47 | −0.20 | 0.14 | 0.155 | 0.232 |
| Accumbens (left) | 8505 | 47 | −0.24 | 0.13 | 0.065 | 0.108 |
| Accumbens (right) | 8519 | 48 | −0.34 | 0.13 | 0.007 | 0.027 |
| Ventricular volume | 8440 | 45 | 0.07 | 0.13 | 0.543 | 0.582 |
In all the cases, results after controlling for the effects of age, sex and brain size. Nsubgroup = number of observations in subgroup, this number changes on the basis of QC for each brain subcortical volume measure; B = difference from CNV non-carriers in z-scores; SE = standard error; p = nominal p-value; pfdr = false discovery rate corrected p-values. Significant p values after false discovery rate correction are highlighted in bold and italic