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. 2020 Apr 14;11:1800. doi: 10.1038/s41467-020-15660-8

Fig. 4. MDS detects the organ tropism of urethane.

Fig. 4

a, b Mean ± SEM mutation frequency each possible CAN to CTN transversion determined by MDS for the non-transcribed strand of exon 2 of Kras in the pancreas or liver of mice (n = 3 mice for pancreas samples from the UR cohort at weeks 1 and 4, 5 mice for liver samples from the UR and PBS cohorts at week 1, and 4 mice for all other cohorts from one experiment) compared with the previous determined mutation frequency in the lung (Fig. 1, n = 7 mice at week 1 and 4 mice at week 4 from one experiment) either (a) 1 week or (b) 4 weeks after exposure to urethane (UR) or PBS. p values calculated by a Holm-Sidak multiple comparisons test following one-way ANOVA or b Dunn’s multiple comparison test following Kruskal–Wallis test. ****p < 0.0001, **p < 0.01, and ns: not significant.