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. 2020 Apr 14;11:1813. doi: 10.1038/s41467-020-15607-z

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a Correlations of intrachromosomal interaction frequency patterns between any two regions along chromosome 19 (300-kb bin). The first principle component (PC1) values are shown under each heatmap as compartments A (magenta) and B (cyan). b The top heatmaps show the mean normalized interaction frequencies for the TADs and their flanking regions with a TAD length of ±0.5. The TADs were defined in the ICM stage and used for all stages. The bottom heatmaps show the difference in the interaction frequencies between consecutive stages. Source data are provided as a Source Data file.