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. 2020 Apr 14;11:1780. doi: 10.1038/s41467-020-15440-4

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a Chemical structure of canonical and NBD conjugated GNF179 and Coumarin-1 conjugated GNF179. b Dose response curves for GNF179 and Coumarin1 (left) or NBD (right) conjugated GNF179 in wild-type and KAF156-resistant clone (KAD452-R3, containing three mutations in pfcarl (M81I, L830V and S1076I). c Colocalization of Coumarin-1 conjugated GNF179 with ER-tracker red. d Colocalization of NBD conjugated GNF179 with ER-tracker red. Parasites are in mid-ring (6-hours post-infection) stage and were treated for 30 min with 2 µM GNF179-Coumarin1 and 100 nM GNF179-NBD. The blue signal represents the DAPI-stained parasite nucleus. Scale bars: 2 µm. Source data for b is provided as a Source Data file.