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. 2020 Apr 14;10:6343. doi: 10.1038/s41598-020-62875-2

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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MSTN expression in infiltrating cells in DN and IgA/FSGS. (A) The graph depicts the levels of MSTN staining evaluated by immunohistochemistry and image analysis. Data are expressed as arbitrary units and as mean ± SEM (*p < 0.05 vs IgA/FSGS). (B) The photos are representative of MSTN expression in infiltrates in DN and (C) in IgA/FSGS biopsies. (D) Double staining with MSTN (red) and CD45 (green) in DN. Merged image shows that MSTN colocalizes with CD45. Panel E shows colocalization MSTN (red)+Megalin/LRP2 (green), a marker of PTECs. MSTN = Myostatin, DN = Diabetic Nephropathy, IgA = immunoglobulin A nephropathy, FSGS = focal segmental glomerulosclerosis, AU = Arbitrary Units. Magnification. Panel B: Upper photos x100 (Bar = 75–150 µm); lower photos, left x630 and right x400 (Bar = 15 µM); Panels C, D and E x400.