Table 2.
IC50s of QACs against A.castellanii.
| Compound | Abbreviation | No. of carbon | CMC (µM) | MW (g/mol) | IC50 | |||
|---|---|---|---|---|---|---|---|---|
| A. castellanii trophozoites | A. castellanii cysts | |||||||
| µg/ml | µM | µg/ml | µM | |||||
| Dodecyltrimethyl ammonium bromide | QAC12 | 12 | 21300* | 308.40 | >150 | >486 | >37.50 | >121.60 |
| tetradecyltrimethyl ammonium bromide | QAC14 | 14 | 5600* | 336.40 | 52.80 ± 0.14 | 156.96 ± 0.12 | >37.50 | >111.47 |
| hexadecyltrimethyl ammonium bromide | QAC16 | 16 | 1300* | 364.50 | 10.80 ± 0.34 | 29.63 ± 0.03 | 19.17 ± 0.56 | 52.59 ± 0.64 |
| octadecyltrimethyl ammonium bromide | QAC18 | 18 | 200 (800)** | 392.50 | 6.90 ± 0.03 | 17.58 ± 0.04 | 15.00 ± 0.34 | 38.21 ± 0.24 |
The CMC of QACs collated from *Jalali-Heravi & Konouz, 2003; **Quan et al., 2007 (Lukac et al., 2013). Data is mean ± SD; n = 4 independent experiments performed in triplicates. Student’s t-test showed significant difference between all treatments for each parasite life cycle stage at p < 0.01.