Table 3.
Back transformation of QAC-treated cysts to trophozoites after drug wash-out.
| Drugs | Drug concentration (µg/ml) | Trophozoites | Cysts | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Hours | |||||||||
| 1 | 24 | 48 | 72 | 96 | 24 | 48 | 72 | ||
| QAC14 | 37.50 | + | + | + | + | + | + | + | + |
| 18.75 | + | + | + | + | + | + | + | + | |
| 9.375 | + | + | + | + | + | + | + | + | |
| QAC16 | 37.50 | − | − | − | − | − | + | − | − |
| 18.75 | + | − | − | − | − | + | + | + | |
| 9.375 | + | + | + | + | + | + | + | + | |
| QAC18 | 37.50 | − | − | − | − | − | − | − | − |
| 18.75 | + | − | − | − | − | + | − | − | |
| 9.375 | + | − | − | − | − | + | + | + | |
| Control | 0.0000 | + | + | + | + | + | + | + | + |
“+”Indicates cells reverting back to trophozoites after washout; and capable of oxidizing reduced alamar blue from blue to pink after 8 days “−” indicates cell that did not revert to trophozoites after wash out and unable to oxidise reduced alamar blue solution