Table 5.

Associations of cognitive and physical functioning with risk of stroke subtype, stratified for apolipoprotein ε4 carriership.

	Ischemic stroke		Hemorrhagic stroke		Unspecified stroke
	ApoE4 carrier	ApoE4 non-carrier	ApoE4 carrier	ApoE4 non-carrier	ApoE4 carrier	ApoE4 non-carrier
Cognitive functioning
MMSE (per point decrease)
n/N	83/2,298	269/5,896	22/2,298	39/5,896	14/2,298	49/5,896
HR (95% CI)	1.01 (0.91–1.12)	1.02 (0.97–1.08)	0.99 (0.80–1.23)	0.90 (0.75–1.09)	1.08 (0.87–1.34)	1.07 (0.98–1.16)
G-factor (per SD decrease)
n/N	67/1,829	204/4,938	15/1,829	29/4,938	10/1,829	34/4,938
HR (95% CI)	1.01 (0.73–1.41)	1.12 (0.94–1.34)	0.76 (0.36–1.60)	1.23 (0.78–1.93)	5.58 (2.31–13.52)	1.65 (1.23–2.21)
Physical functioning
BADL (per SD decrease)
n/N	80/2,024	255/5,288	22/2,024	39/5,288	12/2,024	47/5,288
HR (95% CI)	1.02 (0.79–1.31)	1.17 (1.03–1.33)	1.27 (0.81–1.99)	0.99 (0.69–1.40)	2.01 (1.13–3.58)	1.29 (1.01–1.66)
IADL (per SD decrease)
n/N	83/2,293	270/5,887	22/2,293	39/5,887	14/2,293	16/5,887
HR (95% CI)	1.02 (0.82–1.26)	1.05 (0.94–1.18)	1.14 (0.78–1.67)	1.09 (0.80–1.47)	1.52 (1.03–2.24)	1.08 (0.86–1.35)

ApoE4 = Apolipoprotein ε4; BADL = Basic Activities of Daily Living; CI = confidence interval; HR = hazard ratio; IADL = Instrumental Activities of Daily Living; SD = standard deviation.

Higher scores on MMSE and G-factor indicate better cognitive function. Higher scores on ADL indicate higher independence. All analyses were censored for incident stroke (any stroke). Significant associations are displayed in bold text. Adjusted for age, sex, systolic and diastolic blood pressure, blood pressure-lowering medication, total cholesterol, high-density lipoprotein cholesterol, lipid-lowering medication use, BMI, diabetes mellitus type 2, smoking, alcohol use, and level of education.