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. 2020 Apr 14;10:6395. doi: 10.1038/s41598-020-63148-8

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Differentially expressed transcription factors (TFs) in the differentially expressed genes between HNSCC and nontumor patients. (a) Heat map and (b) volcano plot demonstrating differentially expressed TFs. Red represents upregulated differentially expressed TFs, blue represents downregulated differentially expressed TFs, and black dots (volcano) represent TFs that were not differentially expressed. (c) Differentially expressed TFs and the high-risk survival-associated IRG interaction network. The red line represents positive regulation, and the green line represents negative regulation.