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. 2020 Apr 14;10:6387. doi: 10.1038/s41598-020-63196-0

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© This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Scatter plots of representative OTUs identified as statistically different by Metastats. Percent abundance of the OTU is plotted, and each symbol represents one sample, with the mean shown as a solid line. OTUs decreased (OTU4 and OTU27) or increased (OTU54 and OTU37) in mean abundance from healthy to SIV infected, and subsequently increased (OTU4 and OTU37) or decreased (OTU27 and OTU54) from SIV infected to c-ART treated groups. Calculations were performed from a subsampled dataset. Statistical significance was tested by the mothur implementation of Metastats, with P < 0.05 = *, and P < 0.01 = **.