Table 1.
Structures of various forms of DD superfamily.
| DD superfamily | Proteins | Monomer | Dimer | Filament | Domain swapping |
|---|---|---|---|---|---|
| DD | FADD | O (2GF5) | (3OQ9)a | ||
| Fas | O (1DDF) | (3OQ9)a | O (3EZQ) | ||
| RAIDD | O (2O71) | (2OF5)a | |||
| PIDD | (2OF5)a | ||||
| TRADD | O (5XME) | ||||
| RIP1 | O (6AC5) | ||||
| IRAK-2 | (3MOP)a | ||||
| IRAK-3 | O (5UKE) | ||||
| IRAK-4 | O (2A9I) | (3MOP)a | |||
| Ankyrin-1 | O (2YQF) | ||||
| Ankyrin-2 | O (4D8O) | ||||
| Ankyrin-3 | O (4O6X) | ||||
| TNFRSF1A | O (1ICH)) | ||||
| TNFRSF16 | O (2N83) | ||||
| TNFRSF25 | O (5YGS) | ||||
| MALT1 | O (2G7R) | O (6GK2) | |||
| MyD88 | (3MOP)a | ||||
| NF-kB-1 | O (2DBF) | ||||
| NF-kB-2 | O (2D96) | ||||
| THOC1 | O (1WXP) | ||||
| UNC5B | O (3G5B) | O (1WMG) | |||
| DED | FADD | O (2GF5) | |||
| Caspase-8 | O (5JQE) | O (5L08) | O (6AGW) | ||
| PEA-15 | O (6P6B) | ||||
| CARD | Caspase-1 | O (5FNA) | |||
| Caspase-9 | O (3YGS) | ||||
| Apaf-1 | O (2YGS) | O (3YGS) | |||
| ARC | O (4UZ0) | ||||
| ASC | O (2KN6) | O (6N1H) | |||
| RAIDD | O (3CRD) | ||||
| RIPK2 | O (2N7Z) | O (2N83) | O (6GGS) | ||
| NLRP1 | O (4IFP) | ||||
| NLRC4 | O (4KXF) | O (6N1I) | |||
| NOD1 | O (2B1W) | O (2NSN) | O (2NSN) | ||
| NOD4 | O (2MJM) | ||||
| CARMA1 | O (4LWD) | O (4JUP) | |||
| ICEBERG | O (1DGN) | ||||
| BinCARD | O (4DWN) | ||||
| CARD8 | O (4IKM) | ||||
| CARD9 | O (6E26) | O (6N2M) | O (6N2P) | O (6N2M) | |
| BIRC2 | O (2L9M) | ||||
| MAVS | O (2VGQ) | O (3J6J) | |||
| DDX58 | O (2LWD) | O (4P4H) | |||
| Bcl-10 | O (2MB9) | O (6GK2) | O (6BZE) | ||
| PYD | ASC | O (2KN6) | O (3J63) | ||
| NLRP1 | O (1PN5) | ||||
| NLRP3 | O (3QF2) | ||||
| NLRP4 | O (4EWI) | ||||
| NLRP6 | O (6NDJ) | O (6NCV) | |||
| NLRP7 | O (2KM6) | ||||
| NLRP10 | O (2M5V) | ||||
| NLRP12 | O (2L6A) | O (4XHS) | |||
| NLRP14 | O (4N1L) | O (4N1J) | O (4N1J) | ||
| POP1 | O (2HM2) | ||||
| AIM2 | O (4O7Q) | O (6MB2) | |||
| MEFV | O (2MPC) | ||||
| MNDA | O (5WQ6) |
aIndicates the formation of helical oligomer rather than filaments.