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. 2020 Apr 8;8:208. doi: 10.3389/fbioe.2020.00208

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Copyright © 2020 Tirella, Mattei, La Marca, Ahluwalia and Tirelli.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) Free amino content measured over time for both the 0.75 to 0.05 (black squares) and the 0.75 to 0.10 (white circles) A/DA-NH₂/A_PEGDA soluble models incubated with LOx, GlyO (positive control) and PBS (negative control). (B) Free amino content measured over time for both the 0.25 to 0.05 (black squares) and the 0.75 to 0.10 (white circles) A/DA-NH₂/A_PEGDA crosslinked hydrogels incubated with LOx, GlyO or PBS. Each free amine time series was analyzed independently and found statistically different (one-way ANOVA, p < 0.05).