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Gastroprotective activity of CEX on HCl/EtOH-induced gastric lesions in mice.
| Compound | n | Lesion index (mm) |
% Lesion reduction | Dose (mg/kg) |
|---|---|---|---|---|
| CEX-10 | 7 | 36.6 ± 4.7* | 18** | 10 |
| CEX-25 | 7 | 29.7 ± 3.3* | 34** | 25 |
| CEX-50 | 7 | 16.7 ± 3.9* | 63 | 50 |
| CEX-100 | 7 | 12.0 ± 3.4* | 73 | 100 |
| Lansoprazole | 7 | 15.7 ± 2.9* | 67 | 30 |
| Control | 7 | 45.3 ± 5.3** | – | – |
The results are expressed as mean ± SD. *P < 0.01 compared with the control and **P < 0.01 compared with lansoprazole (ANOVA followed by Dunnett’s test). n = number of mice.
