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. 2020 Apr 8;11:635. doi: 10.3389/fimmu.2020.00635

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Copyright © 2020 Colombo, Bassani, De Angelis, Ruffini, Ottoboni, Comi, Martino and Farina.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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BAF312 inhibits NFκB nuclear translocation and maintains glutamate transporters expression in astrocytes exposed to inflammatory cytokines. (A) Representative immunofluorescence stainings for NFκB-p65 in human iAstrocytes stimulated with cytokines alone or after pre-incubation with BAF312. (B) Graph reports the percentage of NFκB-p65 positive nuclei in human iAstrocytes under distinct conditions. (C–F) Representative immunofluorescence stainings for GLAST (C) and GLT1 (E) in human iAstrocytes and relative quantifications (D,F) under distinct conditions. Representative images are shown. DAPI was used for nuclear staining. Data are shown as mean ± SD of a representative experiment out of three independent experiments. Scale bars: 30 μm. *p < 0.05, **p < 0.01, ***p < 0.001.