Figure 2.

Strategies for cardioprotection. Protective mechanisms for anthracycline-induced cardiotoxicity include the generation of Doxorubicin analogs with reduced toxicity, the combined treatment with protective compounds and targeted therapy approaches including liposomal packaging of Doxorubicin. Liposomal packaging prevents Doxorubicin from exiting the vasculature in tissues with tight endothelial barriers such as the heart, but allows targeting of a tumor with leaky capillaries.