Table 1.
Pharmacokinetics of olinciguat in female and male Sprague Dawley rats.
| PK Parameter | Female | Male | |
|---|---|---|---|
| i.v. | Vss (L/kg) | 0.9 | 1.1 |
| CL (ml/min/kg) | 5.6 | 11.3 | |
| p.o. | Cmax (ng/ml) | 198 | 96.4 |
| Tmax (h) | 3.0 | 1.0 | |
| t1/2 (h) | 3.9 | 3.5 | |
| Oral bioavailability | 45% | 36% | |
Pharmacokinetic parameters were calculated by noncompartmental analysis using sparse sampling. Vss, i.v. steady-state volume of distribution; CL, systemic clearance; Cmax, maximum plasma concentration after p.o. dosing; Tmax, sampling time of the maximum plasma concentration after p.o. dosing; t1/2, half-life during the apparent elimination phase after p.o. dosing.