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. 2020 Apr 8;11:249. doi: 10.3389/fneur.2020.00249

Figure 2.

Figure 2

Serum SNTF is significantly elevated on the day of mTBI and is diagnostic for a subset of the injuries. Between group comparisons and ROC-AUC analyses were evaluated by Mann-Whitney U test. Each study participant was evaluated for serum SNTF a minimum of 4 times. (A) In group analysis, mean serum SNTF levels on the day of mTBI are 92% higher than their mean levels in healthy controls. The bars represent the S.E.M. Between group statistical comparison by two-tailed t-test. (B) In group analysis, median serum SNTF levels on the day of mTBI are 63% higher than their median levels in healthy controls. The filled circles represent each case, and the bars represent quartiles. Note that whereas some of the mTBI cases have serum SNTF levels indistinguishable from the range of the controls, a subset have SNTF levels markedly elevated over the entire control group. Between group statistical comparison by Mann-Whitney U-test. (C) In ROC-AUC curve analysis, serum SNTF levels on the day of mTBI distinguish a subset of injured patients from healthy controls. At a cutoff value of 1.54 U, serum SNTF is 100% specific and 37% sensitive for mTBI. The AUC is 0.87, the 95% confidence interval is 0.80–0.93, and is significantly different from chance (p < 0.0001; Mann-Whitney U test).