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. 2020 Apr 8;11:249. doi: 10.3389/fneur.2020.00249

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Copyright © 2020 Siman, Cui, Wewerka, Hamel, Smith and Zwank.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Serum SNTF on the day of mTBI predicts impaired long-term recovery of cognitive function under stress. Serum levels of the biomarker were evaluated a minimum of 4 times, and analyzed in relation to brain functional measures by Mann-Whitney U test. Recovery of cognitive stress function was determined as the difference in the Stroop Color and Word IS-T scores between 90 and 30 days post-injury. In ROC-AUC analyses, serum SNTF on the day of injury was significantly higher in mTBI with the decile exhibiting the worst functional recovery compared to either the best recovering decile (A) or best recovering quartile (B).