Table 3.
Serum SNTF on the day of mild TBI in relation to other brain performance scores at 3 months post-injury.
| Performance test | SNTF- (sem; n) | SNTF ± (sem; n) | P-value |
|---|---|---|---|
| Rivermead post-concussion symptom questionnaire | |||
| SNTF > 1.45 U COG-3 | 1.8 ± 0.6 (32) | 2.6 ± 0.6 (26) | 0.38 |
| RPQ-13 | 7.1 ± 1.9 (32) | 8.7 ± 2.0 (26) | >0.5 |
| Standardized assessment of concussion | |||
| SNTF > 1.45 U | 24.7 ± 0.4 (61) | 24.9 ± 0.5 (35) | >0.5 |
| Digit span | |||
| SNTF > 1.45 U | 18.0 ± 0.8 (36) | 16.4 ± 0.8 (29) | 0.15 |
| Controlled oral word association | |||
| SNTF > 1.45 U | 39.3 ± 2.1 (37) | 38.9 ± 2.4 (30) | >0.5 |
| Buschke selective reminding | |||
| SNTF > 1.45 U Reminding | 54.6 ± 1.3 (37) | 53.6 ± 1.4 (30) | >0.5 |
| SNTF > 1.45 U Delayed | 8.73 +/0.41 (37) | 9.31 ± 0.37 (30) | 0.26 |
| Trail making | |||
| SNTF > 1.45 U; Trail A speed (s) | 22.5 ± 2.2 (35) | 21.9 ± 1.5 (29) | >0.5 |
| SNTF > 1.45 U; Trail B speed | 52.3 ± 3.7 (35) | 62.6 ± 6.7 (29) | 0.16 |
| SNTF > 1.45 U; Trail A errors | 0.53 ± 0.13 (36) | 0.55 ± 0.15 (29) | >0.5 |
| SNTF > 1.45 U; Trail B errors | 0.94 ± 0.45 (36) | 1.28 ± 0.44 (29) | 0.47 |
In contrast to the significant performance impairments of SNTF-positive participants compared to the SNTF-negative cases in the test results depicted in Table 2, for other tests of cognitive function and self-reported symptomatic scores there was no significant difference as a function of serum SNTF status. The Rivermead, Digit Span, Controlled Oral Word Association, Bushke Selective Reminding, and Trail Making test data shown are at 90 days post-injury. The Standardized Assessment of Concussion was conducted on the day of injury. Serum SNTF was quantified a minimum of 4 times per mTBI study participant.