. 2020 Apr 14;10(4):41. doi: 10.1038/s41408-020-0306-5

Table 2.

Overall survival outcomes based on combined organ response and composite hematologic and organ response (CHOR) model.

	Mayo Clinic cohort				Pavia cohort
	N	Median OS (95% CI)	p-value	Hazard ratio (95% CI), p-value	N	Median OS (95% CI)	p-value	Hazard ratio (95% CI), p-value
Combined organ response
Overall population	473				575
AOR	125	NR (98-NR)		Reference	120	85 (79–100)		Reference
MOR	66	81 (50-NR)	<0.001^a	2.2 (1.3–3.8), p = 0.003	105	62 (50–98)	0.028^a	1.6 (1.0–2.3), p = 0.029
NOR	282	85 months (66–105)	0.71^b	2.4 (1.6–3.7), p < 0.001	350	42 (33–56)	0.062^b	2.1 (1.5–2.0), p < 0.001
>1 organ involved	235				258
AOR	48	NR (81-NR)		Reference	28	82 (77–100)
MOR	66	81 months (50-NR)	0.03^a	2.1 (1.1–4.0), p = 0.02	105	62 (50–98)	0.130^a	1.6 (0.8–3.1), p = 0.13
NOR	109	52 months (35–75)	0.05^b	2.9 (1.7–5.0), p < 0.001	125	34 (23–47)	0.015^b	2.6 (1.4–5.0), p = 0.002
Heart involvement	332				424
AOR	68	NR (81-NR)		Reference	72	84 (73–100)		Reference
MOR	63	81 months (50-NR)	0.05^a	1.8 (1.0–3.3), p = 0.06	102	62 (50–98)	0.05^a	1.4 (0.9-2-2), p = 0.11
NOR	201	63 months (40–78)	0.13^b	2.5 (1.5–4.2), p < 0.001	250	25 (20–38)	0.001^b	2.4 (1.6–3.5), p < 0.001
CHOR model	473				575
Group-1	349	NR (103-NR)		Reference	344	87 (79–98)		Reference
Group-2	124	34 months (21–46)	<0.001	3.4 (2.5–4.6), p < 0.001	231	23 (18–30)	<0.001	2.8 (2.2–3.5), p < 0.001

AOR all organ response, MOR mixed organ response, NOR no organ response, CHOR composite hematologic and organ response, NR not reached, OS overall survival.

^aLog-rank p-value for AOR vs. MOR.

^bLog-rank p-value for MOR vs. NOR.