Table 3.
The dynamics of parameter changes during the treatment.
| Parameter | Mean value 2nd day of treatment | Mean value 3rd day of treatment | Mean value 4th day of treatment | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Placebo group (n = 24) | Treatment group (n = 120) | P value | Placebo group (n = 24) | Treatment group (n = 120) | P value | Placebo group (n = 24) | Treatment group (n = 120) | P value | |
| Weight, Me (IQR), kg |
71.0 (65.5–84.8) |
73.0 (67.0–80.0) |
0.95 |
76.5 (67.5–86.5) |
73.0 (65.0–78.0) |
0.10 |
78.0 (63.5–99.0) |
71.5 (68.0–73.0) |
0.47 |
| DBP, Me (IQR), mm Hg |
75.0 (70–80) |
80 (70–80) |
0.86 |
77.5 (70–80) |
75 (70–80) |
0.86 |
75.5 (70–79) |
70 (70–75) |
0.32 |
| SBP, Me (IQR), mm Hg |
120 (120–120) |
120 (120–120) |
0.20 |
120 (120–120) |
120 (120–120) |
0.10 |
120 (120–120) |
120 (120–120) |
0.56 |
| HR, Me (IQR), b/min | 74.1 ± 2.7 | 73.9 ± 2.6 | 0.49 | 74.1 ± 2.8 | 73.1 ± 3.9 | 0.36 | 74.0 ± 2.5 | 74.0 ± 3.6 | >0.99 |
| ±SD, °С | 36.64 ± 0.15 | 36.63 ± 0.21* | 0.43 | 36.62 ± 0.10 | 36.60 ± 0.15 | 0.39 | 36.57 ± 0.08 | 36.58 ± 0.10 | 0.63 |
| ±SD, times | 3.5 ± 1.9* | 2.8 ± 1.4* | 0.10 | 2.8 ± 1.1* | 2.0 ± 0.9* | 0.03 | 2.1 ± 0.9* | 1.3 ± 0.5* | 0.09 |
| ±SD, tablets | 13.3 ± 1.9 | 12.2 ± 1.0 | — | 13.7 ± 2.2 | 12.0 | — | 12.0 | — | — |
Abbreviations: IQR – interquartile range; T – body temperature; Me – median; SBP – systolic blood pressure; DBP – diastolic blood pressure; HR – heart rate; SD – standard deviation.