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. 2020 Apr 14;11:1822. doi: 10.1038/s41467-020-15529-w

Fig. 5. miR-802 KO mice improves obesity-associated insulin resistance and glucose intolerance when fed with high fat diet (HFD).

Fig. 5

8-week-old male miR-802 KO mice and control mice (miR-802fl/fl) were exposed to HFD for 12 weeks. a Then, Fasting insulin levels (FINS) of HFD-fed mice were measured by ELISA after 12-week of feeding HFD (n = 10). (b, c) Intraperitoneal glucose tolerance test (GTT) (1.5 g kg−1) (b) and intraperitoneal insulin tolerance test (ITT; 0.75 U kg−1) (c) were performed in miR-802 KO mice and control mice at the 11th or 12th week of High fat diet administered, respectively. The corresponding area under the curve (AUC) of blood glucose level was calculated (n = 10). d Homeostatic model assessment indices of insulin resistance (HOMA-IR) of miR-802 KO mice and control mice (n = 10). e, f Insulin release from islets of miR-802 KO mice or control mice after 6-week (e) or 12-week (f) HFD treatment (n = 5). The p-values by two-tailed unpaired Student’s t test (a, d), or two-way ANOVA (b, c, e, f) are indicated. In all panels error bars indicate mean ± SEM, except (e, f) (mean ± SD). Source data are provided as a Source Data file.