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. 2020 Apr 14;11:1778. doi: 10.1038/s41467-020-15671-5

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a The nuclei in whole-slide images are automatically segmented. b For each segmented nucleus, 10 nucleus-level features, regarding nucleus size, staining intensity, shape, and density, are extracted. c For each type of nucleus-level features from the same whole-slide image, they are dissected into 15 image-level features using a 10-bin histogram and five distribution statistics. Scale bars: 5 mm (a whole-slide image) and 50 µm (a image patch).