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. 2020 Mar 2;52(3):409–422. doi: 10.1038/s12276-020-0390-4

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a Luminescence signal of xenografted tumors formed by indicated cells in mice after gemcitabine treatment. b The changes of tumor volume and luminescence with gemcitabine treatment in indicated cells (mean value is plotted). c Representative images of tumor mass removed from mice with xenografted tumors. d Tumor weight (mg) of the collected tumor mass removed from mice xenografted with indicated cancer cells (*P < 0.05). e Representative images of PROM2 and TUNEL immunostaining in indicated tumor tissues; the quantification of results is shown on the right panel (*P < 0.05), the PROM2 expression of vector group has been set as 1.