Table 2.
Enriched pathways of the upregulated phosphoproteins (fold change >1.5) in HuH-7R cells by DAVID based on KEGG pathways.
| Enriched pathway | −Log (p value) | Molecules |
|---|---|---|
| Gap junction | 6.262012674 | RAF1, CDK1, EGFR, ITPR3, MAPK1, MAP3K2, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3E, TUBB2A, TUBB2B, TUBB3, TUBB4B |
| Regulation of actin cytoskeleton | 5.018181393 | CRK, GIT1, IQGAP1, RAF1, ACTB, ACTG1, ARPC1B, CFL1, CFL2, EGFR, ITGA3, MAPK1, MSN, PAK4, PXN, PPP1CA, PPP1R12A, PPP1R12C, RRAS2, SSH2, VCL |
| Focal adhesion | 3.568636236 | CRK, MET, RAF1, ACTB, ACTG1, EGFR, FLNA, FLNB, ITGA3, MAPK1, PAK4, PXN, PPP1CA, PPP1R12A, PPP1R12C, TLN1, VCL, ZYX |
| Adherens junction | 3.432973634 | IQGAP1, MET, ACTB, ACTG1, CTNNA1, CTNNA2, EGFR, MAPK1, MAP3K7, VCL |
| mTOR signaling pathway | 2.657577319 | AKT1S1, RICTOR, RRAGC, MAPK1, PRKAA1, RPTOR, RPS6KA1, RPS6 |
| MAPK signaling pathway | 2.568636236 | CRK, RAF1, CDC25B, DAXX, EGFR, FLNA, FLNB, HSPA1A, HSPB1, MAPT, MAPK1, MAP3K2, MAP3K7, NF1, RRAS2, RPS6KA1, STMN1, ZAK |
| Rap1 signaling pathway | 1.795880017 | CRK, EPHA2, MET, RAP1GAP, RAF1, RAPGEF6, ACTB, ACTG1, EGFR, MAPK1, PRKD1, PRKD2, SIPA1, TLN1 |
Membrane receptors are specifically marked in bold.