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. 2020 Apr 14;10:6398. doi: 10.1038/s41598-020-62193-7

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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EVs isolated from maternal circulation express canonical exosome markers. (A) A representative of Cryo EM image of plasma EVs isolated from normal pregnant individual (scale bar 100 nm). (B) EVs isolated utilizing methodology detailed yielded nanoparticles enriched in exosome markers CD63, TSG101 and flotillin-1 without contamination from cellular debris and apoptotic bodies (cytochrome C). The blots were cropped from different parts of the same gel. (C) Nanoparticle scatter analysis confirmed that majority of isolated EVs had size distribution consistent with exosomes (50–100 nm), and there was no difference in the size distribution of EVs between the Preeclampsia versus Control groups (p = 0.415). (D) Total plasma EV quantities in Preeclampsia versus Control groups were also similar (p = 0.313).