Table 2.

Youden's Index for the performance of the STEV platform in predicting preeclampsia in the presented cohort. STEV signal threshold cut-off of <0.316 was 95.2% sensitive and 95.6% specific for diagnosis of preeclampsia.

Threshold	Sensitivity%	95% CI		Specificity%		95% CI			Likelihood ratio
<0.008	4.762	0.120% to 23.816%		100		85.181% to 100%
<0.029	9.524	1.175% to 30.377%		100		85.181% to 100%
<0.055	14.286	3.049% to 36.342%		100		85.181% to 100%
<0.080	19.048	5.446% to 41.907%		100		85.181% to 100%
<0.092	23.810	8.218% to 47.166%		100		85.181% to 100%
<0.098	28.571	11.281% to 52.175%		100		85.181% to 100%
<0.102	33.333	14.588% to 56.968%		100		85.181% to 100%
<0.116	38.095	18.107% to 61.565%		100		85.181% to 100%
<0.130	42.857	21.820% to 65.979%		100		85.181% to 100%
<0.132	47.619	25.713% to 70.219%		100		85.181% to 100%
<0.134	52.381	29.781% to 74.287%		100		85.181% to 100%
<0.137	57.143	34.021% to 78.180%		100		85.181% to 100%
<0.140	61.905	38.435% to 81.893%		100		85.181% to 100%
<0.152	66.667	43.032% to 85.412%		100		85.181% to 100%
<0.165	71.429	47.825% to 88.719%		100		85.181% to 100%
<0.177	71.429	47.825% to 88.719%		95.652		78.051% to 99.890%			16.429
<0.194	76.190	52.834% to 91.782%		95.652		78.051% to 99.890%			17.524
<0.221	80.952	58.093% to 94.554%		95.652		78.051% to 99.890%			18.619
<0.267	85.714	63.658% to 96.951%		95.652		78.051% to 99.890%			19.714
<0.305	90.476	69.623% to 98.825%		95.652		78.051% to 99.890%			20.810
<0.316	95.238	76.184% to 99.880%		95.652		78.051% to 99.890%			21.905
<0.333	95.238	76.184% to 99.880%		91.304		71.962% to 98.929%			10.952
<0.355	95.238	76.184% to 99.880%		86.957		66.411% to 97.225%			7.302
<0.361	95.238	76.184% to 99.880%		82.609		61.219% to 95.049%			5.476
<0.364	95.238	76.184% to 99.880%		78.261		56.297% to 92.540%			4.381
<0.375	95.238	76.184% to 99.880%		73.913		51.595% to 89.771%			3.651
<0.404	95.238	76.184% to 99.880%		69.565		47.081% to 86.790%			3.129
<0.455	100	83.890% to 100%		69.565		47.081% to 86.790%			3.286
<0.488	100	83.890% to 100%		65.217		42.734% to 83.624%			2.875
<0.491	100	83.890% to 100%		60.870		38.542% to 80.292%			2.556
<0.496	100	83.890% to 100%		56.522		34.495% to 76.809%			2.300
<0.505	100	83.890% to 100%		52.174		30.588% to 73.180%			2.091
<0.543	100	83.890% to 100%		47.826		26.820% to 69.412%			1.917
<0.575	100	83.890% to 100%		43.478		23.191% to 65.505%			1.769
<0.588	100	83.890% to 100%		39.130		19.708% to 61.458%			1.643
<0.624	100	83.890% to 100%		34.783		16.376% to 57.266%			1.533
<0.650	100	83.890% to 100%		30.435		13.210% to 52.919%			1.438
<0.682	100	83.890% to 100%		26.087		10.229% to 48.405%			1.353
<0.714	100	83.890% to 100%		21.739		7.460% to 43.703%			1.278
<0.720	100	83.890% to 100%		17.391		4.951% to 38.781%			1.211
<0.734	100	83.890% to 100%		13.043		2.775% to 33.589%			1.150
<0.760	100	83.890% to 100%		8.696		1.071% to 28.0380%			1.095
<0.797	100	83.890% to 100%		4.348		0.110% to 21.949%			1.045
Threshold	ROC-AUC	P Value	Sensitivity	Specificity	PPV		NPV	Patients		Controls
<0.316	0.975	<0.001	95.2%	95.7%	95.3%		95.6%	n = 21		n = 23