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. 2020 Apr 14;10:6323. doi: 10.1038/s41598-020-62953-5

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Snol-A led CARF suppression caused inhibition of pATM-Chk1 signaling and dose dependent apoptosis. (A) Immunoblots of CARF, ATR, pATR and Chk1 showing decrease in their levels in treated cells; quantitation is shown below. (B) Immunoblots of apoptotic markers showing decrease in PARP 1/2, Pro-caspase-9 and 3 in Snol-A (6 and 10 μM) treated SKOV-3 cells. Increase in their corresponding cleaved bands (PARP1/2 and caspase-3) was found; Quantitation is shown below. (C) Immunostaining showing increase in the cleaved PARP 1/2 in Snol-A treated (2, 6 & 10 µM) SKOV-3 cells. Quantitation of its fluorescent intensities in nucleus is shown at the right.