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. 2020 Apr 14;10:6323. doi: 10.1038/s41598-020-62953-5

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Snol-A caused suppression of tumor growth and lung metastasis in vivo. (A) Schematic model is showing regime of SKOV-3 cell injection (SC and IV; Day 0) and Snol-A treatments including 2 weeks pre-feeding (2 times/week) and on every alternative day for next 4 weeks, post-week of cell injections. Mice were sacrificed, and tumors were dissected and images of lung metastatic nodules were captured and counted. (B) Diagram showing the quantitation of mice body weight in the control and treated group, showing no significant change in these groups. (C) Quantitation of tumor volume (in cu.mm) in control and treated group is shown. A significant decrease in tumor volume in Snol-A treated group was observed. (D) Image showing lung metastatic nodules (circled yellow) in control and Snol-A treated mice. Quantitation of the metastatic nodules is given at the bottom.