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. 2020 Apr 14;10:6396. doi: 10.1038/s41598-020-63357-1

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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LXR activation increases Nrg1 type III expression in sensory neurons of the DRG. (A) Nrg1 type III mRNA level in DRG of mice fed either NC or WD and treated with or without GW3965 with NC group treated as 100% (n = 6/group). (B) Nrg1 type III mRNA level in organotypic culture of DRG stimulated with or without palmitate and treated with or without GW3965 (vehicle group treated as 100%) (n = 4 experiments in triplicate). (C) Nrg1 type III mRNA level in primary neuronal culture of DRG stimulated with or without palmitate and treated with or without GW3965 (vehicle group treated as 100%) (n = 3 experiments in triplicate). (D) Nrg1 type III mRNA level in DRG sensory neurons of RiboTag-Nav mice fed either NC or WD and treated with or without GW3965 with NC-veh group treated as 100% (n = 6/group). (E) Nrg1 type III mRNA level in organotypic culture of DRG sensory neurons (from RiboTag-Nav mice) stimulated with or without palmitate and treated with or without GW3965 (vehicle group treated as 100%) (n = 3 experiments in triplicate). All data are Mean±S.E.M. *p < 0.05; **p < 0.005; ***p < 0.0005.