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. 2020 Apr 14;10:6396. doi: 10.1038/s41598-020-63357-1

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Loss of LXR α/β in sensory neurons decrease neuronal nrg1 expression. (A) LXRα and LXRβ mRNA levels in DRG of LXRα/β cell specific knockout using NaV1.8-Cre with control group set at 100% (n = 6/group). (B) mRNA levels of LXR canonical targets in the DRG of LXRab and LXRabnav mice fed either NC or WD (with LXRab-NC group set to 100%) (n = 6/group). (C) mRNA levels of LXR canonical targets in the sciatic nerve of LXRab and LXRabnav mice fed either NC or WD (with LXRab-NC group set to 100%) (n = 6/group). (D) (B) mRNA levels of ErbB2 and 3 in the sciatic nerve of LXRab and LXRabnav mice fed either NC or WD (with LXRab-NC group set to 100%) (n = 6/group). (E) Electron microscopic images of sciatic nerve from LXRab and LXRabnav mice (scale 4 µm). All data are Mean ± S.E.M. *p < 0.05; **p < 0.005; ***p < 0.0005.