Table 1.
Summary of statistical significance for the nine EMT transcriptional signatures tested in all conditions for both SK-BR-3 and MDA-MB-231 cells.
| SK-BR-3 | MDA-MB-231 | |||
|---|---|---|---|---|
| Non-circulated (control) to circulated (unconfined) | Circulated (unconfined) to constricted | Non-circulated (control) to circulated (unconfined) | Circulated (unconfined) to confined/constricted | |
| Vimentin | − (**) | |||
| E-cadherin | + (**) | − (**) | ||
| N-cadherin | − (***) | |||
| Snail1 | + (**) | + (***) | ||
| Snail2 | − (***) | |||
| Twist1 | − (**) | |||
| Twist2 | + (**) | − (*) | + (***) | |
| ZEB1 | + (***) | |||
| ZEB2 | + (*) | + (*) | ||
Kolmogorov-Smirnov test was used to compare relative expression of all transcripts in for cell type between two conditions/groups. “+” indicates up-regulation and “−” indicates down-regulation of relative expression of transcript. *Significance level at 0.033; **significance level at 0.002; ***significance level < 0.001; ns, not significant.