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. 2020 Apr 14;10:6470. doi: 10.1038/s41598-020-62185-7

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Pathological changes in the organs of mice immunized with the Pn33Fps_HBs conjugated vaccine, Pn33Fps or HBsAg antigen. Histopathological injury was scored semiquantitatively using the scoring standards shown in Table 2.