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. 2020 Apr 14;11:1821. doi: 10.1038/s41467-020-15676-0

Fig. 5. Blockade of β-adrenergic signaling reduces spontaneous metastases in the 4T1-luc breast carcinoma model.

Fig. 5

a Tumor growth of irradiated tumors (left) and non-irradiated tumors (right) is shown. Data are presented as mean ± SEM. **P < 0.01; ***P < 0.001 (two-way ANOVA analysis). n = 12 biologically independent mice in PBS + Rad group and n = 18 biologically independent mice in Prop + Rad group. On Day 33 post tumor implantation, bioluminescent images of luciferase activity b were acquired and histologic analysis of lung tissues was shown in c. Staining with eosin hematoxylin was performed (×40 magnification, scale bars = 500 µm) and black arrows showed metastatic lesions. Data are presented as mean ± SEM. *P < 0.05; **P < 0.01 (Student’s t test analysis). For b and c, n = 5 biologically independent mice in all groups.