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. 2020 Mar 10;52(3):461–472. doi: 10.1038/s12276-020-0387-z

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — In FHF hepatocytes, lncRNA NEAT1 recruits EZH2 to the promoter region of LATS2 and induces the production of H3K27me3, thus repressing the expression of LATS2. Upon inhibition of the LATS2 expression, YAP1 could not be activated and enter the nucleus, which results in binding to P73 and induces the apoptosis mediated by P73.