Table 1.

Composite of morbidity endpoints in relation to tertile distribution of the post-CPB HMGB1 concentration.

	Total(n = 250)	First Tertile (n = 83)(0.337–2.684 ng/ml)	Second Tertile (n = 83)(2.689–5.770 ng/ml)	Third tertile (n = 84)(5.799–28.552 ng/ml)	P value
HMGB1, ng/ml	3.933 [2.018–6.866]	1.734 [1.088–2.019]	3.922 [3.209–4.500]*	8.443 [6.829–12.029]*†	<0.001
Composite morbidity, n (%)	58 (23)	10 (12)	20 (24)*	28 (33)*	0.005
Death, n (%)	10 (4)	0 (0)	4 (5)	6 (7)	0.039
Stroke, n (%)	4 (2)	2 (2)	2 (2)	0 (0)	0.401
Myocardial infarction, n (%)	0 (0)				—
Renal failure, n (%)	29 (12)	2 (2)	9 (11)	18 (21)*	<0.001
Prolonged ventilation> 24 h
Number, n (%)	33 (13)	7 (8)	11 (13)	15 (18)	0.205
Duration (hrs)	17 [14–21]	18 [13–21]	17 [13–20]	17 [15–22]	0.786

Values are expressed as the numbers of patients (%), median [interquartile range]. *P < 0.05 vs. first tertile; ^†P < 0.05 vs. second tertile.

CPB = cardiopulmonary bypass; HMGB1 = high mobility group box 1.