Table 2.

Composite of morbidity in relation to tertile distribution of the baseline HMGB1 concentration.

	Total(n = 250)	First Tertile (n = 83)(0.001–0.348 ng/ml)	Second Tertile (n = 83)(0.351–0.967 ng/ml)	Third tertile (n = 84)(0.982–47.799 ng/ml)	P value
HMGB1, ng/ml	0.620 [0.268–1.551]	0.187 [0.095–0.269]	0.620 [0.483–0.816]*	3.144 [1.520–7.584]*†	<0.001
Composite morbidity, n (%)	58 (23)	16 (19)	22 (27)	20 (24)	0.537
Death, n (%)	10 (4)	4 (5)	4 (5)	2 (2)	0.669
Stroke, n (%)	4 (2)	3 (4)	1 (1)	0	0.131
Myocardial infarction, n (%)	0 (0)				—
Renal failure, n (%)	29 (12)	9 (11)	13 (16)	7 (8)	0.338
Prolonged ventilation> 24 h
Number, n (%)	33 (13)	6 (7)	11 (13)	16 (19)	0.082
Duration (hrs)	17 [14–21]	17 [12–20]	18 [15–22]	18 [15–22]	0.251

Values are expressed as the numbers of patients (%), median [interquartile range]. *P < 0.05 vs. first tertile; ^†P < 0.05 vs. second tertile.

HMGB1 = High mobility group box 1.