Table 3.
Patient characteristics in relation to tertile distribution of post-CPB HMGB1 concentration.
| Total(n = 250) | First tertile (n = 83)(0.337–2.684 ng/ml) | Second tertile (n = 83)(2.689–5.770 ng/ml) | Third tertile (n = 84)(5.799–28.552 ng/ml) | P value | |
|---|---|---|---|---|---|
| Age, yrs | 66.1 ± 11.3 | 66.0 ± 10.2 | 67.0 ± 11.8 | 65.1 ± 11.9 | 0.556 |
| Gender (M/F) | 119/131 | 53/30 | 41/42 | 25/59 | <0.001 |
| Body mass index, kg/m2 | 23.5 ± 5.7 | 24.2 ± 7.3 | 24.0 ± 4.4 | 22.7 ± 5.0 | 0.233 |
| Hypertension, n (%) | 140 (56) | 50 (60) | 49 (59) | 41(49) | 0.263 |
| Diabetes mellitus, n (%) | 59 (24) | 22 (27) | 23 (28) | 14 (17) | 0.187 |
| Cerebrovascular accident, n (%) | 21 (8) | 9 (11) | 9 (11) | 3 (4) | 0.128 |
| Coronary artery disease, n (%) | 60 (24) | 15 (18) | 27 (33) | 18 (21) | 0.073 |
| Single-vessel | 26 (10) | 11 (13) | 10 (12) | 5 (6) | |
| Double-vessel | 17 (7) | 4 (5) | 7 (8) | 6 (7) | |
| Triple-vessel | 17 (7) | 0 (0) | 10 (12) | 7 (8) | |
| Previous myocardial infarction, n (%) | 14 (6) | 3 (4) | 8 (8) | 3 (4) | 0.175 |
| Congestive heart failure (NYHA III,IV), n (%) | 73 (29) | 13 (16) | 29 (35) | 31 (37) | 0.004 |
| Left ventricular ejection fraction, n (%) | 60 ± 13 | 62 ± 13 | 58 ± 14 | 60 ± 11 | 0.175 |
| Preoperative creatinine, mg/dl | 0.88 [0.68–1.11] | 0.86 [0.67–0.99] | 0.87 [0.73–1.27] | 0.90 [0.67–1.13] | 0.272 |
| Preoperative medication, n (%) | |||||
| Beta-blockers | 85 (34) | 26 (31) | 32 (39) | 27 (32) | 0.574 |
| Renin-angiotensin system antagonists | 110 (44) | 29 (35) | 39 (47) | 42 (50) | 0.118 |
| Calcium-channel blockers | 74 (30) | 23 (28) | 27 (33) | 24 (29) | 0.802 |
| EuroSCORE II | 6.2 ± 3.3 | 5.1 ± 3.3 | 6.4 ± 3.3* | 6.9 ± 3.1* | 0.001 |
Values are expressed as the numbers of patients (%), mean ± standard deviation, median [interquartile range]. *P < 0.05 vs. first tertile.
CPB = cardiopulmonary bypass; HMGB1 = High mobility group box 1; NYHA = New York Heart Association.