Table 4.
Perioperative data in relation to tertile distribution of post-CPB HMGB1 concentration.
| Total(n = 250) | First tertile (n = 83)(0.337–2.684 ng/ml) | Second tertile (n = 83)(2.689–5.770 ng/ml) | Third tertile (n = 84)(5.799–28.552 ng/ml) | P value | |
|---|---|---|---|---|---|
| Cardiac procedure, n (%) | 0.076 | ||||
| Valve | 213 (85) | 76 (91) | 63 (76) | 74 (88) | |
| Valve and CABG | 22 (9) | 4 (5) | 12 (14) | 6 (7) | |
| Valve and aortic procedure | 15 (6) | 3 (4) | 8 (10) | 4 (5) | |
| Type of valve, n (%) | 0.095 | ||||
| Mechanical | 93 (37) | 26 (31) | 28 (34) | 39 (46) | |
| Bioprosthesis | 157 (63) | 57 (69) | 55 (66) | 45 (54) | |
| Cardiopulmonary bypass, min | 115 [85–151] | 98 [70–117] | 115 [85–150]* | 149 [103–200]*† | <0.001 |
| Postoperative blood loss, ml | 704 [502–763] | 715 [500–760] | 600 [500–760] | 730 [512–900] | 0.123 |
| Postoperative pRBC transfusion, n % | 56 (22) | 22 (27) | 18 (22) | 16 (19) | 0.508 |
| Intensive care unit stay, day | 3 [2–4] | 2 [2,3] | 3 [2,3] | 3 [2–5] | 0.030 |
| Hospital stay, day | 15 [11–18] | 12 [9–15] | 15 [11–18]* | 18 [13–29]*† | <0.001 |
Values are expressed as the numbers of patients (%), median [interquartile range]. *P < 0.05 vs. first tertile; †P < 0.05 vs. second tertile. CPB = cardiopulmonary bypass; HMGB1 = High mobility group box 1; CABG = coronary artery bypass graft; pRBC = packed erythrocytes.