Table 2.
Combination indices (CI) for U251, ULM-GBM-PC38, ULM-GBM-PC40 and ULM-GBM-PC128 glioblastoma cells treated with the indicated concentrations of ONC201/TIC10 and 2-Deoxyglucose.
| ONC201/TIC10 [µM] | 2-Deoxyglucose [mM] | U251 | ULM-GBM-PC38 | ULM-GBM-PC40 | ULM-GBM-PC128 |
|---|---|---|---|---|---|
| CI | CI | CI | CI | ||
| 50.0 | 10.0 | 0.47373 | 1.04881 | 0.33512 | 1.40290 |
| 50.0 | 0.625 | 0.05934 | 0.21674 | 0.08282 | 0.32259 |
| 25.0 | 5.0 | 0.50843 | 0.67757 | 0.31775 | 0.84413 |
| 25.0 | 0.125 | 0.01275 | 0.29085 | 0.17130 | 0.46780 |
| 12.5 | 2.5 | 0.21513 | 0.39476 | 0.24273 | 0.73843 |
| 6.25 | 5.0 | 0.41143 | 0.76281 | 0.55511 | 0.90978 |
| 6.25 | 1.25 | 0.29965 | 0.25774 | 0.17162 | 0.52630 |
| 3.125 | 10.0 | 0.74977 | 1.35216 | 0.63504 | 1.40078 |
| 3.125 | 0.625 | 0.11225 | 0.44404 | 0.14308 | 0.45498 |
A CI < 1 indicates synergism, a CI = 1 indicates additive action and a CI > 1 indicates antagonism.