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Tryptophan‐2, 3‐dioxygenase (TDO) activities tend to be increased in livers of AT‐2 engrafted rats. A, B, mRNA (A) and protein levels of TDO2 (B) in the liver after 5 weeks of tumor inoculation. C, TDO activities in the liver. D, Correlation between TDO activities and kynurenine concentration (Kyn conc.) in liver. Pearson’s correlation coefficient (R) and P values are reported. E, NADPH levels in liver. PC, Positive control (HepG2 cell homogenates)
