Table 1.

Tryptophan (Trp), kynurenine (Kyn), and serotonin concentrations (pmol/mg tissue) and Kyn / Trp ratio in tissues

	Trp			Kyn			Kyn / Trp			Serotonin
	Control	AT‐2 engrafted	P value	Control	AT‐2 engrafted	P value	Control	AT‐2 engrafted	P value	Control	AT‐2 engrafted	P value
Liver	74.3 ± 7.6	73.0 ± 4.6	.88	1.1 ± 0.1	1.3 ± 0.2	.44	0.014 ± 0.001	0.018 ± 0.003	.15	4.3 ± 0.4	22.7 ± 6.1	<.05
Jejunum	101.0 ± 18.6	106.2 ± 34.3	.90	0.7 ± 0.1	0.8 ± 0.2	.63	0.009 ± 0.002	0.011 ± 0.004	.59	26.1 ± 3.7	23.8 ± 1.9	.59
Ileum	128.4 ± 25.5	124.4 ± 34.0	.93	2.1 ± 0.6	1.7 ± 0.3	.55	0.022 ± 0.011	0.021 ± 0.007	.95	33.0 ± 4.0	25.3 ± 3.1	.16
Spleen	106.7 ± 6.8	80.0 ± 4.6	<.05	0.7 ± 0.1	0.8 ± 0.1	.51	0.007 ± 0.001	0.011 ± 0.001	<.05	20.5 ± 0.8	14.3 ± 3.8	.14
Thymus	52.0 ± 1.3	52.8 ± 2.4	.79	1.5 ± 0.2	4.1 ± 0.7	<.01	0.028 ± 0.004	0.078 ± 0.011	<.01	8.0 ± 0.6	19.8 ± 1.4	<.01
Tumor		64.6 ± 4.5			4.1 ± 2.4			0.060 ± 0.031			7.2 ± 1.2

Data are the means ± SD (N = 6 per group).

P values indicate the significance of t tests between control and AT‐2 engrafted rats.