Table 1.
Characteristics of patients with multiple myeloma treated with lenalidomide and dexamethasone
| Number of patients | 48 (100) |
| Age (y) | |
| Median (range) | 69 (45‐84) |
| Sex | |
| Male/female | 19/29 |
| M‐protein | |
| IgG | 21 (44) |
| IgA | 11 (23) |
| BJP | 11 (23) |
| IgD | 4 (8) |
| Nonsecretory | 1 (2) |
| Stage (ISS) | |
| I | 11 (23) |
| II | 20 (42) |
| III | 17 (35) |
| RT‐PCR and FISH | |
| CCND1 | 15 (33) |
| t(11;14)+ | 8 (53) |
| 11 polysomy | 3 (20) |
| NA | 2 (13) |
| ND | 2 (13) |
| FGFR3 | 11 (23) |
| t(4;14)+ | 10 (91) |
| NA | 1 (9) |
| c‐MAF | 7 (15) |
| t(14;16)+ | 5 (71) |
| NA | 2 (29) |
| Triple negative a | 11 (27) |
| ND | 4 (8) |
| ASCT | |
| +/− | 14/34 |
| Prior therapies | |
| Median (range) | 2 (1‐6) |
| Prior bortezomib therapy | |
| +/− | 43 (90)/5 |
| Prior thalidomide therapy | |
| +/− | 11 (23)/37 |
| Best response | |
| CR | 3 (6) |
| VGPR | 5 (10) |
| PR | 24 (50) |
| SD | 13 (27) |
| PD | 2 (4) |
| NE | 1 (2) |
Data are shown as n (%) unless otherwise indicated.
Abbreviations: ASCT, autologous stem cell transplantation; BJP, Bence Jones protein; CR, complete response; ISS, International Staging System; NA, no abnormality; ND, not done; NE, not evaluated; PD, progressive disease; PR, partial response; SD, stable disease; VGPR, very good partial response.
a
CCND1‐, FGFR3‐, c‐MAF‐negative in RT‐PCR.