Table 3.
Pregnancy outcomes in relation to preconception leptin
| Model | Among Pregnancies | ||
|---|---|---|---|
|
Middle vs Low Tertilea RR (95% CI) |
High vs Low Tertilea RR (95% CI) |
||
|
Preterm delivery (n = 50) |
Model 1b | 1.11 (0.69‐2.09) | 1.21 (0.63‐2.33) |
| Model 2c | 1.16 (0.61‐2.20) | 1.24 (0.62‐2.49) | |
| Model 3d | 1.08 (0.57‐2.03) | 1.11 (0.57‐2.16) | |
| Model 4e | 1.15 (0.57‐2.32) | 1.38 (0.54‐3.54) | |
|
Gestational diabetes (n = 22) |
Model 1b | 7.25 (0.89‐58.90) | 18.65 (2.46‐141.44)* |
| Model 2c | 7.38 (0.91‐59.79) | 18.37 (2.39‐141.55)* | |
| Model 3d | 7.18 (0.88‐58.28) | 17.99 (2.36‐137.00)* | |
| Model 4e | 8.30 (1.01‐68.54) | 24.24 (2.67‐219.64)* | |
|
Hypertensive disorders of pregnancy (n = 56) |
Model 1b | 1.13 (0.56‐2.27) | 2.42 (1.30‐4.50)* |
| Model 2c | 1.16 (0.57‐2.39) | 2.35 (1.20‐4.61)* | |
| Model 3d | 1.09 (0.54‐2.18) | 2.14 (1.15‐3.99)* | |
| Model 4e | 1.49 (0.47‐2.21) | 1.62 (0.69‐4.59) | |
Abbreviations: BMI, body mass index; CI, confidence interval; hCG, human chorionic gonadotropin; RR, risk ratios; WHR, waist‐to‐hip ratio.
Reference is the low tertile.
Model 1 is restricted to women who achieved an hCG‐detected pregnancy, with inverse probability weights used control for potential selection bias introduced by restricting to women who achieved pregnancy. Weights were based on factors associated with becoming pregnancy, including age, parity, marital status, number of prior losses, and treatment assignment. Weighted log‐binomial regression was used to estimate risk ratios and 95% confidence intervals.
Model 2 adjusted for age and WHR.
Model 3 adjusted for age, WHR, and fasting status.
Model 4 adjusted for age and BMI.