Figure 7.

The schematic model showing the cooperative effect between zinc finger protein 148 (ZNF148) and Forkhead box M1 (FOXM1) on Snail transcription in SDHB‐deficient gastrointestinal stromal tumor (GIST) cells. Loss of SDHB function leads to accumulation of intracellular succinate, which results in elevated H3K36me2 levels at ZNF148 promoter region and increased ZNF148 expression. ZNF148 can be phosphorylated by ERK at Ser306; this phosphorylation leads to ZNF148 binding to FOXM1 and, thus, facilitates FOXM1‐targeted Snail transcription that links to tumor cell invasion