Figure 9.

Schematic representation of KIF3A inducing triple negative breast cancer (TNBC) cell proliferation, migration and metastasis. KIF3A inhibits p21 expression to promote activity of cyclin‐dependent kinases (CDKs). Consequent Rb phosphorylation by Cyclin/CDK complexes leads to the release of Rb‐E2F complexes, resulting in increasing the expression of E2F and cell cycle‐related proteins, which increases cell cycle progression and finally promotes TNBC cell proliferation. KIF3A also leads to increased expression of MMPs and ZEB1, promoting processes of EMT, which finally accelerates TNBC cell migration and metastasis