Table 3.

Univariate and multivariate analysis of prognostic variables for distant metastasis in cohort 1, patients with rectal cancer treated with neoadjuvant chemoradiotherapy

	Univariate	Multivariate
	P	HR	95% CI	P
Age (≤60 vs >60)	.321
Sex (male vs female)	.417
Distance from anal verge (≥4 cm vs <4 cm)	.013	2.07	0.89‐5.05	.100
pT stage (T1/2 vs T3/4))	.002	3.73	1.22‐14.09	.020*
pN (negative vs positive)	.037	1.97	0.80‐4.61	.138
LVI (negative vs positive)	.038	1.20	0.44‐3.70	.732
Histological type (differentiated vs others)	.196
TRG (non‐responder vs responder)	.048	0.52	0.16‐1.49	.229
p‐mTOR expression (low vs high)	.057
p‐S6 expression (low vs high)	.006	4.51	1.67‐15.69	.002*

Abbreviations: CI, confidence interval; Differentiated, well to moderately differentiated adenocarcinoma; HR, Hazard ratio; Location, Location of primary tumor; LVI, lymphovascular invasion; p‐mTOR expression, phosphorylated mammalian target of rapamycin expression level based on the results of immunohistochemical staining; pN, pathological lymph node metastasis; p‐S6 expression, phosphorylated S6 ribosomal protein expression level based on the result of immunohistochemical staining; pT, pathological T stage; TRG, tumor regression grade.

^* P < 0.05