Figure 4.

Tied Diffusion through Interacting Events (TieDIE) integration reveals specific tolerant networks in mixed‐lineage leukemias (MLL). A, Flow diagram depicting the integration of gene expression and proteome datasets for TieDIE analysis. B, TieDIE analysis identified 56 exosomes regulatory proteins as “upstream” of the integrated network. C, TieDIE analysis identified 48 differently expressed genes as “downstream” of the integrated network. D, Enriched cancer hallmarks generated by dataset integration using TieDIE after inclusion of the gene expression and proteomic data. E, Detailed P‐value of enriched cancer hallmark pathways