Figure 6.

Anthrax toxin receptor 1 (ANTXR1) promotes the tumorigenesis of gastric cancer (GC) cells and promotes GC progression through activation of the PI3K/AKT/mTOR signaling pathway. A, B, Overexpression (OE) of ANTXR1 promoted tumor growth in the nude mouse model by xenograft growth assay. C, D, Tumor weights and tumor volumes in the empty vector control group and the ANTXR1‐overexpressed group. E, H&E staining and immunohistochemistry for ANTXR1, Ki67, E‐cadherin, N‐cadherin, and Vinculin in the empty vector control group and the ANTXR1‐overexpressed group. F, G, Western blot analysis of phosphorylated (p‐)PI3K, PI3K, p‐AKT, AKT, p‐mTOR, and mTOR expression in ANTXR1‐silenced cells, ANTXR1‐overexpressed cells, and ANTXR1‐overexpressed cells treated with LY294002. *P < .05, **P < .01, ***P < .001