Chavanet 1992.

Methods	A single‐centre trial with enrolment from June to December 1991. Location of study: France Loss to follow‐up: Amp Glucose 4/11 (36%) Amp Fat 0/11 (0%) Analysis: no ITT
Participants	Eligibility criteria: Patients who had oral candidiasis, 18 years and older, HIV positive Exclusion criteria: Esophagitis, oral Kaposi, hyperlipidaemia, known intolerance to amphotericin, pancreatitis, serum creatinine > 115 umol/l. Diagnosis confirmed using mycological analysis 22 patients enrolled Amphot‐glucose :11 Amphot‐fat : 11
Interventions	Amphotericin deoxycholate dissolved in either: 5% glucose (amphotericin glucose) ‐ final concentration 1.6 g amphotericin / l or parenteral fat emulsion (amphotericin fat emulsion) ‐ final concentration 2 g amphotericin / l Given as a 1 hour infusion of 1 mg/kg/day on four consecutive days.
Outcomes	Clinical scores of candidiasis ‐ 9 sites were inspected for the presence or absence of candidiasis which were examined for confluent, patchy or scattered lesions scored as 3,2 and 1 respectively. Evaluated the reduction in clinical score. Mycologic cure : culture from swab Clinical and biological tolerance Serum concentrations of amphotericin Adverse events: more frequent with glucose preparation. Chills and fever were most frequent side effect ‐ 66% vs 4%. Sweating and Nausea slightly less frequent in Fat emulsion group.
Notes	Ethics: Ethics approval obtained from local ethics committee, informed consent obtained from patients. Enrolment: June ‐ December 1991.
Risk of bias
Bias	Authors' judgement	Support for judgement
Adequate sequence generation?	Low risk	"..patients were assigned randomly to one of the two treatment groups. Group selection was determined by sequential assignment from a table of random numbers.."
Allocation concealment?	High risk	Sealed envelopes. Each envelope was opened immediately before the treatment was given.
Blinding? All outcomes	High risk	No blinding was used.
Incomplete outcome data addressed? All outcomes	Low risk	Reasons given for discontinuation of intervention